Look at the three-step pathway for the conversion of 3-phosphoglycerate to serine:
$3-phosphoglycerate \xrightarrow[]{1} 3-phosphohydroxypyruvate \xrightarrow[]{2} 3-phosphoserine \xrightarrow[]{3} serine$
When the cell has plenty of serine available, which enzyme in the pathway, 1, 2 or 3, is most likely to be inhibited?

ANALYSIS This is a simple, linear pathway (with no branching). The pathway is most likely controlled by feedback control of the final product.

Question

Look at the three-step pathway for the conversion of 3-phosphoglycerate to serine:

[latex]3-phosphoglycerate \xrightarrow[]{1} 3-phosphohydroxypyruvate \xrightarrow[]{2} 3-phosphoserine \xrightarrow[]{3} serine[/latex]

When the cell has plenty of serine available, which enzyme in the pathway, 1, 2 or 3, is most likely to be inhibited?

ANALYSIS This is a simple, linear pathway (with no branching). The pathway is most likely controlled by feedback control of the final product.

Accepted Answer

Assuming that feedback control is the simplest control mechanism for this linear pathway, serine, the product of the pathway, will inhibit the first enzyme in the pathway when sufficient serine is available in the cell.

Question 19.4: Look at the three-step pathway for the conversion of 3-phosp...

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