Coenzymes
Describe the reactive part of each of the following coenzymes and the way each participates in metabolic pathways:
a. FAD b. NAD+
a. The oxidized form of FAD undergoes reduction when two nitrogen atoms in the flavin part react with 2H+ and 2 e− to give FADH2. The coenzyme FAD is utilized in oxidation reactions that produce carbon-carbon double bonds (C=C).
b. The oxidized form of NAD+ undergoes reduction when a carbon atom in the nicotinamide part reacts with 2H+ and 2 e−, to give NADH and H+. The coenzyme NAD+ is utilized in oxidation reactions that produce carbon-oxygen double bonds (C=O).