Question 18.CC.10: Degradation of Amino Acids Describe the reactions and functi......

Chemistry: An Introduction to General, Organic, and Biological Chemistry [1013382]

Degradation of Amino Acids
Describe the reactions and functions of transamination and oxidative deamination.

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Transamination involves the transfer of an amino group from an amino acid to an α-keto acid such as α-ketoglutarate to form a new amino acid (glutamate) and an α-keto acid. This new α-keto acid provides a carbon skeleton that can enter the citric acid cycle for energy production.
Oxidative deamination involves the removal of an amino group from an amino acid as an ammonium ion, and the oxidation of that carbon to regenerate an α-keto acid. The α-keto acid is usually α-ketoglutarate, which can undergo transamination reactions with other amino acids.

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