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Question 24.5: Fatty Acid Synthesis Malonyl ACP is required for the elongat......

Fatty Acid Synthesis

Malonyl ACP is required for the elongation of fatty acid chains.

a. Complete the following equations for the formation of malonyl ACP from the starting material:

Acetyl CoA + HCO_3^- + ATP →

Malonyl CoA + HS—ACP →

b. What enzymes catalyze these reactions?

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a. Acetyl CoA combines with bicarbonate to form malonyl CoA, which reacts with ACP to form malonyl ACP.

\begin{aligned} & \text { Acetyl } CoA + HCO _3{ }^{-}+ ATP \longrightarrow \text { malonyl } CoA + ADP + P _{ i }+ H ^{+} \\ & \text {Malonyl } CoA + HS – ACP \longrightarrow \text { malonyl ACP }+ HS – CoA \end{aligned}

b. The enzyme for the first reaction is acetyl CoA carboxylase. The enzyme for the second reaction is malonyl CoA transacylase.

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