Question 22.7: Regulation of Glycolysis How is glycolysis regulated by each......

General, Organic, and Biological Chemistry Structures of Life [1002561]

Regulation of Glycolysis

How is glycolysis regulated by each of the following enzymes?
a. hexokinase b. phosphofructokinase c. pyruvate kinase

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a. High levels of glucose-6-phosphate inhibit hexokinase, which stops the addition of a phosphate group to glucose in reaction 1.
b. Phosphofructokinase, which catalyzes the formation of fructose-1,6-bisphosphate, is inhibited by high levels of ATP, and activated by high levels of ADP and AMP.
c. High levels of ATP or acetyl CoA inhibit pyruvate kinase, which stops the formation of pyruvate in reaction 10.

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