Question 9.SSE.4: What is the difference between a nucleoside and a nucleotide......
What is the difference between a nucleoside and a nucleotide?
Step-by-Step
A nucleoside is formed when 1-position of a pyrimidine (cytosine, thiamine or uracil) or 9-position of a purine (guanine or adenine) base is attached to C-l of sugar (ribose or deoxyribose) by a β – linkage. Thus, in general, nucleosides may be represented as: sugar-Base. For example,structure (I) represents a nucleoside.
A nucleotide contains all the three components of nucleic acids, that is, a phosphoric acid group, a pentose sugar and a nitrogenous base. These are obtained by esterification of C5’— OH group of the pentose sugar by phosphoric acid.
Thus, in general, a nucleotide is represented as
\begin{matrix} &&&&&& O \\ &&&&&& || \\ \text {Sugar} & – & \text {Base} & – & O & -& P & – & OH \\ &&&&&& || \\ &&&&&& O\end{matrix}For example,structure (II) represents a nucleotide.
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