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Question 26.3: A tRNA has an anticodon, 5′ AAG 3′. Which amino acid will th...

A tRNA has an anticodon, 5′ AAG 3′. Which amino acid will this tRNA carry? What are the steps necessary for the amino acid to bind to the tRNA?

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Solution
The amino acid is leucine, as the codon is 5′ CUU 3′. Remember that sequences are read from left to right as 5′→3′, so you have to flip the anticodon around to see how it would bind to the codon. Leucine has to be activated by ATP. A specifi c enzyme, leucine-tRNA synthetase, catalyzes the carboxyl ester bond formation between the carboxyl group of leucine and the —OH group of tRNA.

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