Question 21.8: An mRNA has the sequence of codons 5' CCC AGA GCC 3'. If a p...
An mRNA has the sequence of codons 5′ CCC AGA GCC 3′. If a point mutation in the DNA changes the mRNA codon of AGA to GGA, how is the amino acid sequence affected in the resulting protein?
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The mRNA sequence 5′ CCC AGA GCC 3′ codes for the following amino acids: proline, arginine, and alanine. When the point mutation occurs, the new sequence of the mRNA codons is 5′ CCC GGA GCC 3′,which codes for proline, glycine, and alanine. The polar basic amino acid arginine is replaced by the nonpolar amino acid glycine.
Normal | After Point Mutation | |
mRNA codons | 5′ \boxed{CCC} \boxed{AGA} \boxed{GCC} 3′ | 5′ \boxed{CCC} \boxed{GGA} \boxed{GCC} 3′ |
Amino acid sequence | \boxed{Pro} — \boxed{Arg} — \boxed{Ala} | \boxed{Pro} — \boxed{Gly} — \boxed{Ala} |
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