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Question 21.1: Are the following reactions exergonic or endergonic? (a) Glu...

Are the following reactions exergonic or endergonic?
(a) Glucose 6-phosphate → Fructose 6-phosphate ΔG = 0.5 kcal/mol
(b) Fructose 6-phosphate + ATP → Fructose 1,6-bisphosphate + ADP  ΔG = -3.4 kcal/mol

ANALYSIS Exergonic reactions release free energy, and ΔG is negative. Endergonic reactions gain free energy, and so ΔG is positive.

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Reaction (a), the conversion of glucose 6-phosphate to fructose 6-phosphate has a positive ΔG; therefore it is endergonic. Reaction (b), the conversion of fructose 6-phosphate to fructose 1,6-bisphosphate has a negative ΔG; therefore it is exergonic.

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