Question 18.9: ATP Production from β-Oxidation How much ATP will be produce...

Chemistry an Introduction to General, Organic, and Biological Chemistry

ATP Production from β-Oxidation

How much ATP will be produced from the β-oxidation of palmitic acid, a $C_{16}$ saturated fatty acid?

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ANALYZE THE PROBLEM	Number of	Number of	Number of	Number of	Number of
	Carbon Atoms	β-Oxidation Cycles	$\pmb{FADH_2}$	NADH	Acetyl-CoA
	16	7	7	7	8

16-Carbon palmitic acid requires seven β-oxidation cycles, which produce seven $FADH_2$ and seven NADH. The total number of acetyl-CoA is eight. During electron transport, each $FADH_2$ produces two ATP, and each NADH produces three ATP. Each acetyl-CoA can produce 12 ATP by way of the citric acid cycle. Two ATP are utilized in the activation of palmitic acid.

ATP Production from Palmitic Acid $\pmb{(C_{16})}$
Activation of palmitic acid	-2 ATP
$7 \cancel{FADH_2} \times \frac{2 ATP}{\cancel{FADH_2}}$ (electron transport)	14 ATP
$7 \cancel{NADH} \times \frac{3 ATP}{\cancel{NADH}}$ (electron transport)	21 ATP
$8 \cancel{\text{acetyl}-CoA} \times \frac{12 ATP}{\cancel{\text{acetyl}-CoA}}$ (citric acid cycle)	96 ATP
Total	129 ATP

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