Question 21.2: Draw the structure of the amino acid glycine at each pH: (a)...
Draw the structure of the amino acid glycine at each pH: (a) 6; (b) 2; (c) 11.
Analysis
A neutral amino acid exists in its zwitterionic form (no net charge) at its isoelectric point, which is pH ≈ 6. The zwitterionic forms of neutral amino acids appear in Table 21.2 . At low pH ( ≤ 2), the carboxylate anion is protonated and the amino acid has a net positive (+1) charge. At high pH ( ≥ 10), the ammonium cation loses a proton and the amino acid has a net negative (−1) charge.
Table 21.2 The 20 Common Naturally Occurring Amino Acids | |||||
Neutral Amino Acids | |||||
Name | Structure | Abbreviations | Name | Structure | Abbreviations |
Alanine | ![]() |
Ala A | Phenylalanine* | ![]() |
Phe F |
Asparagine | ![]() |
Asn N | Proline | ![]() |
Pro P |
Cysteine | ![]() |
Cys C | Serine | ![]() |
Ser S |
Glutamine | ![]() |
Gln Q | Threonine* | ![]() |
Thr T |
Glycine | ![]() |
Gly G | Tryptophan* | ![]() |
Trp W |
Isoleucine* | ![]() |
Ile I | Tyrosine | ![]() |
Tyr Y |
Leucine* | ![]() |
Leu L | Valine* | ![]() |
Val V |
Methionine* | ![]() |
Met M | Arginine* | ![]() |
Arg R |
Aspartic acid | ![]() |
Asp D | Histidine* | ![]() |
His H |
Glutamic acid | ![]() |
Glu E | Lysine* | ![]() |
Lys K |
Essential amino acids are labeled with an asterisk (*). |
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a. At pH = 6, the neutral, zwitterionic form of glycine predominates
b. At pH = 2, glycine has a net +1 charge
c. At pH = 11, glycine has a net −1 charge.
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