Question 21.2: Draw the structure of the amino acid glycine at each pH: (a)...

Draw the structure of the amino acid glycine at each pH: (a) 6; (b) 2; (c) 11.

Analysis

A neutral amino acid exists in its zwitterionic form (no net charge) at its isoelectric point, which is pH ≈ 6. The zwitterionic forms of neutral amino acids appear in Table 21.2 . At low pH ( ≤ 2), the carboxylate anion is protonated and the amino acid has a net positive (+1) charge. At high pH ( ≥ 10), the ammonium cation loses a proton and the amino acid has a net negative (−1) charge.

Table 21.2 The 20 Common Naturally Occurring Amino Acids
Neutral Amino Acids
Name Structure Abbreviations Name Structure Abbreviations
Alanine Ala A Phenylalanine* Phe F
Asparagine Asn N Proline Pro P
Cysteine Cys C Serine Ser S
Glutamine Gln Q Threonine* Thr T
Glycine Gly G Tryptophan* Trp W
Isoleucine* Ile I Tyrosine Tyr Y
Leucine* Leu L Valine* Val V
Methionine* Met M Arginine* Arg R
Aspartic acid Asp D Histidine* His H
Glutamic acid Glu E Lysine* Lys K
Essential amino acids are labeled with an asterisk (*).
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a. At pH = 6, the neutral, zwitterionic form of glycine predominates

b. At pH = 2, glycine has a net +1 charge

c. At pH = 11, glycine has a net 1 charge.

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