Question 17.9: How might you use an enamine reaction to prepare the followi...

Organic Chemistry with Biological Applications

How might you use an enamine reaction to prepare the following compound?

S t r a t e g y

The overall result of an enamine reaction is the Michael addition of a ketone as donor to an α,β-unsaturated carbonyl compound as acceptor, yielding a 1,5-dicarbonyl product. The C–C bond made in the Michael addition step is the one between the α carbon of the ketone donor and the β carbon of the unsaturated acceptor.

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