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Question 26.1: Polymerase II both initiates the transcription and performs ...

Polymerase II both initiates the transcription and performs the elongation. What are the two forms of the enzyme in these processes? What chemical bond formation occurs in the conversion between these two forms?

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Solution
The phosphorylated form of Pol II performs the elongation, and the unphosphorylated form initiates the transcription. The chemical bond formed in the phosphorylation is the phosphoric ester between the —OH of serine and threonine residues of the enzyme and phosphoric acid.

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