Holooly Plus Logo

Question 22.6: The protein transferrin is involved in the transport of iron...

The protein transferrin is involved in the transport of iron into cells. Iron accumulation in the human body has been implicated in diseases such as Parkinson’s, Alzheimer’s, and thalassemia. The chelating ligand deferoxamine (DFO) is used to treat thalassemia; the complex between iron and DFO is eliminated from the body. Given the formation constants for the complexation of iron(III) by transferrin (Equation 1) and the reaction of DFO with iron (Equation 2), calculate the equilibrium constant for the ligand exchange reaction between DFO and transferrin (Equation 3).

Fe^{3+}(aq) + transferrin(aq) \rightleftharpoons Fe(transferrin)^{3+}(aq)

K_{f,1} = 4.7 \times  10^{20}           (1)

Fe^{3+}(aq) + DFO(aq) \rightleftharpoons Fe(DFO)^{3+}(aq)

K_{f,2} = 4.0 \times  10^{30}           (2)

Fe(transferrin)^{3+}(aq) + DFO(aq) \rightleftharpoons Fe(DFO)^{3+}(aq) + transferrin(aq)

K_{3} =?           (3)

The "Step-by-Step Explanation" refers to a detailed and sequential breakdown of the solution or reasoning behind the answer. This comprehensive explanation walks through each step of the answer, offering you clarity and understanding.
Our explanations are based on the best information we have, but they may not always be right or fit every situation.
The blue check mark means that this solution has been answered and checked by an expert. This guarantees that the final answer is accurate.
Learn more on how we answer questions.
Already have an account?

Related Answered Questions