What polypeptide would be synthesized from the following template strand of DNA:
CGG TGT CTT TTA?
Analysis
To determine what polypeptide is synthesized from a DNA template, two steps are needed. First use the DNA sequence to determine the transcribed mRNA sequence: C pairs with G, T pairs with A, and A (on DNA) pairs with U (on mRNA). Then use the codons in Table 17.3 to determine what amino acids are coded for by a given codon in mRNA.
Table 17.3 The Genetic Code—Triplets in Messenger RNA
Third Base (3′ end) |
Second Base | First Base (5′ end) |
|||||||
G | A | C | U | ||||||
U | Cys | UGU | Tyr | UAU | Ser | UCU | Phe | UUU | U |
C | Cys | UGC | Tyr | UAC | Ser | UCC | Phe | UUC | |
A | Stop | UGA | Stop | UAA | Ser | UCA | Leu | UUA | |
G | Trp | UGG | Stop | UAG | Ser | UCG | Leu | UUG | |
U | Arg | CGU | His | CAU | Pro | CCU | Leu | CUU | C |
C | Arg | CGC | His | CAC | Pro | CCC | Leu | CUC | |
A | Arg | CGA | Gln | CAA | Pro | CCA | Leu | CUA | |
G | Arg | CGG | Gln | CAG | Pro | CCG | Leu | CUG | |
U | Ser | AGU | Asn | AAU | Thr | ACU | Ile | AUU | A |
C | Ser | AGC | Asn | AAC | Thr | ACC | Ile | AUC | |
A | Arg | AGA | Lys | AAA | Thr | ACA | Ile | AUA | |
G | Arg | AGG | Lys | AAG | Thr | ACG | Met | AUG | |
U | Gly | GGU | Asp | GAU | Ala | GCU | Val | GUU | G |
C | Gly | GGC | Asp | GAC | Ala | GCC | Val | GUC | |
A | Gly | GGA | Glu | GAA | Ala | GCA | Val | GUA | |
G | Gly | GGG | Glu | GAG | Ala | CGG | Val | GUG |