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Question 19.5: Determining Feedback Control Points Look at the three-step p......

Determining Feedback Control Points

Look at the three-step pathway for the conversion of 3-phosphoglycerate to serine:
3-phosphoglycerate \xrightarrow[]{1} 3-phosphohydroxypyruvate \xrightarrow[]{2}

3-phosphoserine \xrightarrow[]{3} serine

When the cell has plenty of serine available, which enzyme in the pathway, 1, 2, or 3, is most likely to be inhibited?
ANALYSIS This is a simple, linear pathway. The pathway is most likely controlled by feedback control of the final product.

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Assuming that feedback control is the simplest control mechanism for this linear pathway, serine, the product of the pathway, will inhibit the first enzyme in the pathway when sufficient serine is available in the cell.

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