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Question 16.52: The reaction of methyllithium with an epoxide followed by ne......

The reaction of methyllithium with an epoxide followed by neutralization gives an alcohol. Write the product of the reaction of cyclohexene oxide with methyl lithium, showing the structure in its most stable conformation.

لقطة الشاشة 2023-08-15 195731
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Reaction of the methyl carbanion inverts the configuration at the center where it attacks. Thus, the methyl group and the hydroxyl group are trans in the product. The most stable conformation is diequatorial.

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